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Flupentixol and melitracen tablets (Deanxit)

Common name:
Flupentixol and Melitracen Tablets
Product No.:
C14202003314
Approval No.:
H20171104 (original h20130126)
Main functions:
Mild and moderate depression and anxiety. Neurasthenia, psychogenic depression, depressive neurosis, occult depression, psychosomatic diseases with anxiety and apathy, menopausal depression, anxiety and depression of alcoholics and drug addicts.
Product specification:
20s (delixin)
Manufacturer:
Denmark Lingbei Pharmaceutical Co., Ltd
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Product name Flupentixol and melitracen tablets (Deanxit)
Main raw materials This product is a compound preparation. Its main components are: droperidol hydrochloride and melitracen hydrochloride.
Main role Mild and moderate depression and anxiety. Neurasthenia, psychogenic depression, depressive neurosis, occult depression, psychosomatic diseases with anxiety and apathy, menopausal depression, anxiety and depression of alcoholics and drug addicts.
Suitable population
Product specification 20s (delixin)
Usage and dosage Adults: usually 2 tablets a day: one in the morning and one at noon; In severe cases, the morning dose can be increased to 2 tablets. The maximum dosage is 4 tablets per day. Elderly patients: take one tablet in the morning. Maintenance dose: usually 1 tablet a day, oral in the morning. For cases of insomnia or serious anxiety, it is recommended to reduce the dosage or take mild sedatives in the acute stage.
manufacturing enterprise Denmark Lingbei Pharmaceutical Co., Ltd
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[drug name] Flupentixol and melitracen tablets (Deanxit)

[common name] Flupentixol and Melitracen Tablets

[specification and model] 20s (delixin)

[manufacturer] Denmark Lingbei Pharmaceutical Co., Ltd

[drug type] Western medicine

[approval No.] H20171104 (original h20130126)

[validity period] 36 months

[functional indications] Mild and moderate depression and anxiety. Neurasthenia, psychogenic depression, depressive neurosis, occult depression, psychosomatic diseases with anxiety and apathy, menopausal depression, anxiety and depression of alcoholics and drug addicts.

[usage and dosage] Adults: usually 2 tablets a day: one in the morning and one at noon; In severe cases, the morning dose can be increased to 2 tablets. The maximum dosage is 4 tablets per day. Elderly patients: take one tablet in the morning. Maintenance dose: usually 1 tablet a day, oral in the morning. For cases of insomnia or serious anxiety, it is recommended to reduce the dosage or take mild sedatives in the acute stage.

[adverse reactions] There are few adverse reactions at the recommended dose, which are transient restlessness and insomnia. In clinical trials, the following adverse reactions were observed: nervous system: common: dizziness (2.1%), tremor (2.1%), uncommon: fatigue (1%). Mental disorders: common sleep disorders (6%), restlessness (2.5%), restlessness (1.7%). Visual dysfunction: common: Accommodation disorder (1.5%). Gastrointestinal discomfort: common: dry mouth (5.4%), constipation (1.5%). The above adverse reactions can also be seen in the symptoms of depression itself. Generally speaking, these symptoms weaken the improvement of depression. Post marketing situation: there are individual cases of cholestatic hepatitis. See the inner packaging instructions for details.

[precautions] The following patients should be cautious in using this product: organic brain injury, convulsion * seizure, urinary retention, hyperthyroidism, Parkinson syndrome, myasthenia gravis, late liver disease, cardiovascular and other circulatory diseases. Due to its excitatory properties, this product is not recommended for excited and hyperactive patients. If the patient has been treated with sedatives before, it must be stopped gradually. Unless the depressive symptoms have been significantly reduced, patients with depression are still at risk of suicide. During treatment, patients with suicidal tendencies should not receive a large amount of drugs. Based on reports of other psychotropic drugs, this product may change insulin and glucose tolerance, which requires that diabetic patients should adjust the dosage of hypoglycemic agents when using this product. For patients with angle closure glaucoma and shallow anterior chamber, the use of this product will stimulate pupil dilation and lead to acute attack of glaucoma. The use of tricyclic and tetracyclic antidepressants during local anesthesia will increase the risk of arrhythmia and hypotension. If possible, stop using this product a few days before surgery. If emergency surgery is unavoidable, be sure to inform the anesthesiologist of his previous history of antidepressant treatment. As with all neurodepressants, this product is rare (potentially fatal) in the development of neurodepressant syndrome. Extrapyramidal symptoms may occur in very rare cases, especially in the early stage of Flupentixol treatment. Irreversible tardive dyskinesia may occur when neuroinhibitors such as droperidol are used for long-term treatment. There is evidence that the decrease of physical activity is related to the increase of the risk of thrombosis. Because nerve inhibitors have sedative effect, they can reduce the physical activity of patients. Therefore, special attention should be paid to asking patients whether they have symptoms of venous embolism and encouraging patients to take physical exercise. Since the patient's condition and taking this product can weaken the patient's attention and reaction, the patient taking this product shall not drive or operate dangerous machines. Please read the instructions carefully and follow the doctor's advice.

[taboo] It is forbidden to be allergic to melitracen, droperidol or any inactive ingredient in this product. It is prohibited for circulatory failure, inhibition of the central nervous system caused by any cause (such as acute alcohol, barbiturates or opioids poisoning), coma, adrenal pheochromocytoma, hemocachexia, and untreated angle closure glaucoma. It is not recommended for patients with early recovery of myocardial infarction, various degrees of heart block, arrhythmia and coronary artery ischemia. It is forbidden to use it together with monoamine oxidase inhibitor. The combination of melitracen with monoamine oxidase inhibitors (including non selective, selective monoamine oxidase-A inhibitors (such as moclobemide) and monoamine oxidase-B inhibitors (such as selegilan) may lead to serotonin syndrome, including fever, myoclonus, stiffness, tremor, excitement, panic, confusion and autonomic nervous system dysfunction (i.e. circulatory disorder) And other symptoms. Like other tricyclic antidepressants, melitracen cannot be used in patients who are taking monoamine oxidase inhibitors. The treatment of this product can not be started until 14 days after stopping the non selective monoamine oxidase inhibitors and selegilan, and at least 1 day after stopping moclobemide. Similarly, the treatment of monoamine oxidase inhibitors should also be started after 14 days after stopping the drug.

[listing Permit Holder] Denmark Lingbei Pharmaceutical Co., Ltd

[packaging unit] box

[main ingredients] This product is a compound preparation. Its main components are: droperidol hydrochloride and melitracen hydrochloride.

[character] This product is a Corydalis sugar film coated tablet, which turns white or off white after removing the sugar coating.

[medication for pregnant and lactating women] It is best not to take this product during pregnancy and lactation. Animal reproductive toxicity studies have shown that the compound composed of two active ingredients, droperidol and melitracen, has no harmful effect on embryonic development, but no control study has been conducted on pregnant women. Therefore, the use of this product during pregnancy must be cautious. Since the withdrawal symptoms of newborns cannot be ruled out, it is recommended to gradually reduce the use of this product within 14 days before the due date of delivery A small amount of droperidol is secreted through breast milk. Generally speaking, the average milk concentration / serum concentration ratio is 1:3, which has no effect on children at the therapeutic dose level. The total intake of children is small in terms of body weight. No animal and human studies have been conducted on whether there is meritroxin secretion in breast milk. However, other tricyclic drugs, such as amitriptyline and noramitriptyline, are only found in breast milk Micro secretion.

[medication for children] There is still a lack of research data on the safety and effectiveness of children's medication, and this product is not recommended for children.

[medication for elderly patients] Take one tablet in the morning. Maintenance dose: usually take one tablet every day and take it orally in the morning.

[storage] Store in a cool place below 20 ℃

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