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Azithromycin tablets (cisumide)

It is applicable to the following infections caused by sensitive bacteria: lower respiratory tract infections such as bronchitis and pneumonia; Skin and soft tissue infections; Acute otitis media; Sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections (penicillin is a common drug for the treatment of suppurative streptococcal pharyngitis and for the prevention of rheumatic fever. Azithromycin can effectively remove Streptococcus in the oropharynx, but there is no data on the efficacy of azithromycin in the treatment and prevention of rheumatic fever). Azithromycin can be used for simple genital infection caused by Chlamydia trachomatis in sexually transmitted diseases of men and women. Azithromycin can also be used for simple genital infection caused by non multidrug resistant Neisseria gonorrhoeae and chancre caused by Haemophilus Duke (co infection of Treponema pallidum should be excluded). More role
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Common name:
Azithromycin tablets
Product No.:
B14202031135
Approval No.:
Gyzz h10960167 (inquired by the State Drug Administration)
Jianke price:
¥79.00
Product specification:
0.25g*4s 0.1g * 6 bags 0.25g*6s
Manufacturer:
Pfizer Pharmaceuticals Limited
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      Product name Azithromycin tablets (cisumide)
      Main raw materials Each tablet contains azithromycin dihydrate, equivalent to 0.25g azithromycin.
      Main role It is applicable to the following infections caused by sensitive bacteria: lower respiratory tract infections such as bronchitis and pneumonia; Skin and soft tissue infections; Acute otitis media; Sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections (penicillin is a common drug for the treatment of suppurative streptococcal pharyngitis and for the prevention of rheumatic fever. Azithromycin can effectively remove Streptococcus in the oropharynx, but there is no data on the efficacy of azithromycin in the treatment and prevention of rheumatic fever). Azithromycin can be used for simple genital infection caused by Chlamydia trachomatis in sexually transmitted diseases of men and women. Azithromycin can also be used for simple genital infection caused by non multidrug resistant Neisseria gonorrhoeae and chancre caused by Haemophilus Duke (co infection of Treponema pallidum should be excluded).
      Product specification 0.25g*6s
      Usage and dosage Oral administration once a day, swallow the whole tablet, and take it together with food. Azithromycin tablets are used to treat various infectious diseases. The course of treatment and usage are as follows: for children with sexually transmitted diseases caused by Chlamydia trachomatis, Haemophilus Duke or sensitive Neisseria gonorrhoeae, 1000mg is only required once. Treatment of other infections: the total dose is 1500mg, 500mg once a day for three days. Or the total dose is the same, take 500mg on the first day, and take 250mg orally once a day from the second to the fifth day.
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      [drug name] Azithromycin tablets (cisumide)

      [common name] Azithromycin tablets

      [specification and model] 0.25g*6s

      [manufacturer] Pfizer Pharmaceuticals Limited

      [drug type] Western medicine

      [approval No.] Gyzz h10960167

      [validity period] 60 months

      [functional indications] It is applicable to the following infections caused by sensitive bacteria: lower respiratory tract infections such as bronchitis and pneumonia; Skin and soft tissue infections; Acute otitis media; Sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections (penicillin is a common drug for the treatment of suppurative streptococcal pharyngitis and for the prevention of rheumatic fever. Azithromycin can effectively remove Streptococcus in the oropharynx, but there is no data on the efficacy of azithromycin in the treatment and prevention of rheumatic fever). Azithromycin can be used for simple genital infection caused by Chlamydia trachomatis in sexually transmitted diseases of men and women. Azithromycin can also be used for simple genital infection caused by non multidrug resistant Neisseria gonorrhoeae and chancre caused by Haemophilus Duke (co infection of Treponema pallidum should be excluded).

      [usage and dosage] Oral administration once a day, swallow the whole tablet, and take it together with food. Azithromycin tablets are used to treat various infectious diseases. The course of treatment and usage are as follows: for children with sexually transmitted diseases caused by Chlamydia trachomatis, Haemophilus Duke or sensitive Neisseria gonorrhoeae, 1000mg is only required once. Treatment of other infections: the total dose is 1500mg, 500mg once a day for three days. Or the total dose is the same, take 500mg on the first day, and take 250mg orally once a day from the second to the fifth day.

      [adverse reactions] 1. Although it is not certain that all events were caused by azithromycin, we still report all adverse events collected in the report during the clinical trial and after the product was put on the market. The patients had good tolerance and low incidence of adverse reactions. The following adverse events were observed in clinical trials: (1) Abnormal blood and lymphatic system: transient neutropenia is occasionally seen in clinical trials, but there is no data indicating that it is related to azithromycin. Abnormal ear and labyrinth: some patients had hearing impairment after taking azithromycin, including hearing loss, tinnitus and / or deafness. According to the investigation and research, this phenomenon is related to the continuous high-dose use of this product. Through the follow-up of these patients, it is found that the hearing of most patients can be recovered. (2) Gastrointestinal abnormalities: nausea, vomiting, diarrhea, loose stool, abdominal discomfort (pain or spasm), gastrointestinal flatulence. (3) Abnormal hepatobiliary system: abnormal liver function. 2. Skin and subcutaneous soft tissue abnormalities: allergic reactions including rash and angioneuroedema. Other adverse events reported during the use of this product after marketing include: (1) Infection and colonization: candidiasis and vaginitis. (2) Abnormal blood and lymphatic system: thrombocytopenia. (3) Abnormal immune system: allergic reaction (rarely fatal). (4) Metabolic and nutritional abnormalities: anorexia. (5) Mental disorders: aggressive reaction, neuroticism, anxiety, anxiety. (6) Nervous system abnormalities: dizziness, convulsion (similar to other macrolides), headache, increased activity, sensory retardation, paresthesia, drowsiness, fainting. There are few reports of taste / smell reversal and / or loss. However, it is not clear whether it is related to medication. (7) Abnormal ear and labyrinth: vertigo. (8) Cardiac abnormalities: palpitations and arrhythmias, including ventricular tachycardia (like other macrolides), have been reported; QT interval prolongation and torsade de pointe ventricular tachycardia are rarely reported. However, it has not been confirmed that the above adverse events are related to azithromycin. (9) Vascular abnormalities: hypotension. (10) Gastrointestinal abnormalities: vomiting / diarrhea (rare dehydration), dyspepsia, constipation, pseudomembranous enteritis, pancreatitis, tongue discoloration (rare), etc. (see the inner package manual for details)

      [precautions] 1. Like erythromycin and other macrolides, there are few reports of serious allergic reactions, such as angioedema and allergies (rarely fatal). Some reactions caused by azithromycin can occur repeatedly and require long-term observation and treatment. 2. Since the liver is the main way of azithromycin clearance, azithromycin should be used cautiously in patients with obvious liver disease. 3. It has been reported that ergot poisoning occurs when patients treated with ergot derivatives take some macrolide antibiotics at the same time. Although there is no data indicating that ergot interacts with azithromycin, azithromycin and ergot derivatives should not be administered at the same time due to the possibility of ergot poisoning in theory. 4. Like other antibiotic preparations, we should pay attention to the symptoms of double infection caused by non sensitive bacteria, including fungi. 5. Almost all antimicrobial applications have reported Clostridium difficile associated diarrhea (CDAD), including azithromycin, whose severity can range from mild diarrhea to fatal enteritis. Antimicrobial treatment can cause the change of normal flora of colon and lead to the excessive growth of Clostridium difficile. Toxin A and toxin B produced by Clostridium difficile are related to the pathogenesis of CDAD. High incidence rate of Clostridium difficile leads to increased morbidity and mortality. These infections may not be effective for antimicrobial therapy, and may require colectomy. For all patients with diarrhea after antibiotic use, the possibility of CDAD must be considered. Since there have been reports of CDAD after more than 2 months of antimicrobial treatment, the medical history should be carefully inquired. 6. In patients with severe renal insufficiency (glomerular filtration rate)<10ml/min)中,阿奇霉素的全身暴露量增加了33%。 7.有报道,应用其他大环内酯类抗生素可引起心脏再极化和QT间期延长,从而有发生心律失常和尖端扭转型室性心动过速的危险。当患者心脏再极化延长的危险性增加时,不能完全除外阿奇霉素也有上述类似的作用。 8.无证据提示阿奇霉素对患者驾驶和操作机器的能力产生影响。 (详见包装内部说明书)请仔细阅读说明书并遵医嘱使用。

      [taboo] This product is contraindicated for patients allergic to azithromycin, erythromycin, other macrolide or ketolactone antibiotics, or any excipients.

      [listing Permit Holder] Pfizer Pharmaceuticals Limited

      [packaging unit] box

      [main ingredients] Each tablet contains azithromycin dihydrate, equivalent to 0.25g azithromycin.

      [character] This product is a white or film coated tablet, which appears white or off white after removing the coating.

      [applicable population] unlimited

      [medication for pregnant and lactating women] Animal reproductive studies show that azithromycin can pass through the placenta, but there is no sign of damage to the fetus. There is no safety data on the secretion of azithromycin in breast milk and its use in pregnant and lactating people, so it can be used only when pregnant or lactating women have no appropriate choice. (see the inner package manual for details)

      [medication for children] No matter what kind of infection, it is recommended that the total dose of azithromycin in children should not exceed 1500mg. Azithromycin tablets are only suitable for children whose weight is greater than 45kg, and the usage and dosage are the same as that of adults. The pharmacokinetic data of children suggest that the dose of 20mg / kg in children is equivalent to that of 1200mg in adults, but its Cmax value is higher. There is no safety for children to use this product to prevent avian intracellular Mycobacterium complex And efficacy data. According to the pharmacokinetic data of children, the dose of 20mg / kg is equivalent to that of 1200mg in adults, but its Cmax value is higher. For children with streptococcal pharyngitis, the single dose of azithromycin 10mg / kg or 20mg / kg is proved to be effective for 3 consecutive days, but the daily dose shall not exceed 500mg. In the clinical trials comparing the two dosing regimens, the clinical efficacy of the two regimens is similar, but 20m Of course, penicillin is still the first choice for routine treatment of suppurative streptococcal pharyngitis, including the prevention of rheumatic fever. (see the inner package manual for details)

      [medication for elderly patients] The administration method and dose are the same as that of adults.

      [storage] Seal and store in a dry place.

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        Azithromycin tablets (cisumide)

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