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Donepezil hydrochloride tablets (Allison)

Treatment of mild or moderate symptoms of Alzheimer's disease. More role
App download minus 10 yuan
Common name:
Donepezil Hydrochloride Tablets
Product No.:
B14202011986
Approval No.:
Gyzz h20050978 (inquired by the State Drug Administration)
Jianke price:
¥177.00
Product specification:
5mg * 7S * 1 plate 10mg * 7S * 1 plate
Manufacturer:
Weicai (China) Pharmaceutical Co., Ltd
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Product name Donepezil hydrochloride tablets (Allison)
Main raw materials The main ingredient of this product is donepezil hydrochloride.
Main role Treatment of mild or moderate symptoms of Alzheimer's disease.
Product specification 5mg * 7S * 1 plate
Usage and dosage Oral. 1. Adults / elderly: the initial treatment dosage is 1 tablet once a day (calculated as donepezil hydrochloride 5mg). Donepezil hydrochloride should be taken orally before going to bed at night. The dose of 5mg a day should be maintained for at least one month to evaluate the early clinical response and reach the steady-state blood concentration of donepezil hydrochloride. After treatment of 5mg a day for one month and clinical evaluation, the dose of donepezil hydrochloride can be increased to once a day, two tablets at a time (10mg based on donepezil hydrochloride). The recommended maximum dose is 10mg. No clinical trials have been conducted for doses greater than 10mg a day. After stopping treatment, the efficacy of donepezil hydrochloride decreased gradually. There was no rebound after discontinuation of treatment. 2. Liver / kidney dysfunction: For patients with renal function and mild to moderate liver dysfunction, the elimination of donepezil hydrochloride is not affected, so the method of taking donepezil is similar to that of normal people. For patients with mild to moderate liver dysfunction, due to possible effects (see pharmacokinetics), it is recommended to adjust the dose appropriately according to individual tolerance. There is no data on patients with severe liver dysfunction.
manufacturing enterprise Weicai (China) Pharmaceutical Co., Ltd
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[drug name] Donepezil hydrochloride tablets (Allison)

[common name] Donepezil Hydrochloride Tablets

[specification and model] 5mg * 7S * 1 plate

[manufacturer] Weicai (China) Pharmaceutical Co., Ltd

[drug type] Western medicine

[approval No.] Gyzz h20050978

[validity period] 36 months

[functional indications] Treatment of mild or moderate symptoms of Alzheimer's disease.

[usage and dosage] Oral. 1. Adults / elderly: the initial treatment dosage is 1 tablet once a day (calculated as donepezil hydrochloride 5mg). Donepezil hydrochloride should be taken orally before going to bed at night. The dose of 5mg a day should be maintained for at least one month to evaluate the early clinical response and reach the steady-state blood concentration of donepezil hydrochloride. After treatment of 5mg a day for one month and clinical evaluation, the dose of donepezil hydrochloride can be increased to once a day, two tablets at a time (10mg based on donepezil hydrochloride). The recommended maximum dose is 10mg. No clinical trials have been conducted for doses greater than 10mg a day. After stopping treatment, the efficacy of donepezil hydrochloride decreased gradually. There was no rebound after discontinuation of treatment. 2. Liver / kidney dysfunction: For patients with renal function and mild to moderate liver dysfunction, the elimination of donepezil hydrochloride is not affected, so the method of taking donepezil is similar to that of normal people. For patients with mild to moderate liver dysfunction, due to possible effects (see pharmacokinetics), it is recommended to adjust the dose appropriately according to individual tolerance. There is no data on patients with severe liver dysfunction.

[adverse reactions] The most common adverse reactions were diarrhea, muscle spasm, fatigue, nausea, vomiting and insomnia. Some adverse reactions other than individual cases are listed below according to the organs, systems and frequency of adverse reactions. The frequency of adverse reactions is defined as follows: common (& gt; 1 / 100, & lt; 1 / 10), rare (& gt; 1 / 1000, & lt; 1 / 100), rare (& gt; 1 / 10000, & lt; 1 / 1000). Common: common cold, anorexia, diarrhea, vomiting, nausea, rash, pruritus, hallucinations * *, irritability * *, aggressive behavior * *, fainting *, dizziness, insomnia, gastrointestinal dysfunction, muscle spasm, urinary incontinence, headache, fatigue, pain and accidental injury. Rare: epilepsy *, bradycardia, gastrointestinal bleeding, gastric and duodenal ulcer, slight increase of blood creatine kinase concentration. Rare: extrapyramidal symptoms, sinoatrial block, atrioventricular block, abnormal liver function, including hepatitis.

[precautions] Donepezil hydrochloride treatment should be started and supervised by a physician experienced in the diagnosis and treatment of Alzheimer's disease. Diagnosed by recognized standards (such as DSM IV, ICD10), donepezil treatment can be started only when the patient has a reliable caregiver and can often monitor the patient's medication. Treatment can continue as long as the benefits of treatment for patients remain. Therefore, the clinical efficacy of donepezil should be reassessed regularly. Discontinuation of treatment should be considered when the benefits of treatment no longer exist. The response of each patient to donepezil cannot be predicted. The effect of donepezil hydrochloride on patients with severe Alzheimer's disease, other types of dementia or other types of memory impairment (such as age-related cognitive impairment) has not been fully observed. Anesthesia: donepezil hydrochloride is a cholinesterase inhibitor, which may enhance the muscle relaxation effect of succinylcholine drugs during anesthesia. Cardiovascular system: cholinesterase inhibitor can produce vagal effect on heart rate (such as bradycardia) due to its pharmacological effect. Patients with "sick sinus syndrome" or other supraventricular heart conduction diseases should pay special attention. Syncope and epilepsy have been reported. Special attention should be paid to patients who may have heart block or sinus arrest. *In patients with syncope or epilepsy, cardiac block or long-term sinus space should be considered. **In case of mental disorder symptoms (hallucinations, irritability, aggressive behavior), reduce the dose or stop the medication. See the inner packaging instructions for details. Please read the instructions carefully and follow the doctor's advice.

[taboo] It is prohibited for patients with a history of allergy to donepezil hydrochloride, piperidine derivatives or excipients in preparations. It is forbidden for pregnant women. This preparation contains lactose. It is forbidden for patients with rare genetic problems such as galactose intolerance, Lapp lactase deficiency or glucose galactose malabsorption.

[listing Permit Holder] Weicai (China) Pharmaceutical Co., Ltd

[packaging unit] box

[main ingredients] The main ingredient of this product is donepezil hydrochloride.

[character] This product is film coated tablets. It turns white after removing the film coating.

[applicable population] Adult, elderly

[medication for pregnant and lactating women] 1. Pregnancy: no teratogenicity was found in the teratogenicity experiments in pregnant rats with about 80 times human dose and rabbits with 50 times human dose. However, in the experiment of pregnant rats with 50 times human dose, stillbirth increased slightly from 17 days of pregnancy to 20 days after delivery, and the survival rate of offspring decreased slightly 4 days after delivery. However, no abnormal effect was found at the next low dose of about 15 times the human dose. At present, there is no clinical data of donepezil in pregnant women. Therefore, this product is forbidden for pregnant women. 2. There is no research data on the safety and effectiveness of medication for lactating women, so women taking this product cannot breastfeed.

[medication for children] Donepezil hydrochloride is not recommended for children.

[medication for elderly patients] See item l of [usage and dosage] for details.

[storage] Store at room temperature.

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    Donepezil hydrochloride tablets (Allison)

    ¥177.00

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